The game has been stated for a November 20, 2012 release.
The first in-depth trailer for the game shows Agent 47 storming a safehouse, and confronting Diana while she is showering. 47 is "betrayed by those he once trusted and now hunted by the police, he suddenly finds himself at the center of a dark conspiracy and must embark on a personal journey through a corrupt and twisted world, in his search for the truth". At least one portion of the game will be set in Chicago, and the game will take place in the United States. Hitman: Absolution is set at the end of the timeline. Confirmed plot details include series protagonist Agent 47 assassinating his former International Contract Agency handler Diana Burnwood early in the game and the antagonist is Blake Dexter, a new character to the series. The character will be voiced by Keith Carradine.
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Hitman:Absolution Trailer - YouTube
Hitman Absolution Trailer - Saints - YouTube